Search on: I-KAPPA B PROTEINS 
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Descriptor English:   I-kappa B Proteins 
Descriptor Spanish:   Proteínas I-kappa B 
Descriptor Portuguese:   Proteínas I-kappa B 
Synonyms English:   I kappa B
I-kappa B
IkB DNA-Binding Proteins
I kappa B Proteins
IkB DNA Binding Proteins  
Tree Number:   D12.644.360.365
D12.776.260.420
D12.776.476.381
D12.776.930.326
Definition English:   A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. 
See Related English:   I-kappa B Kinase
NF-kappa B
Proto-Oncogene Proteins c-rel
 
History Note English:   2006(2000) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   34471 
Unique Identifier:   D020672 

Occurrence in VHL:
 

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